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Cytokine production by CD4 and CD8 T cells during the growth of Mycobacterium tuberculosis in mice

Clinical and Experimental Immunology, ISSN: 0009-9104, Vol: 113, Issue: 3, Page: 443-449
1998
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Article Description

Changes in the pattern of cytokines found in CD4 and CD8 T cells during the growth of Mycobacterium tuberculosis that resulted in the establishment of a latent infection were monitored. Subsets of T cells were identified based on their differential expression of CD45 and CD44 which allowed them to be classified as naive, activated or memory. We found that the T cells in the lung produced a predominantly type 1 cytokine response. The appearance of large numbers of Th1 cells coincided with the establishment of latency. In contrast, the predominant response in the mediastinal lymph node and spleen was a Th2-type response.

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