PlumX Metrics
Embed PlumX Metrics

Antiadipogenic properties of retinol in primary cultured differentiating human adipocyte precursor cells

International Journal of Cosmetic Science, ISSN: 0142-5463, Vol: 22, Issue: 2, Page: 95-103
2000
  • 11
    Citations
  • 0
    Usage
  • 14
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

The aim of this study was to investigate the effect or retinol on the human adipose conversion process using primary cultured human adipocyte precursor cells. When these cells were seeded in a medium containing retinol (concentrations ranging from 3.5 nM to 3.5 μM), cell proliferation was slightly inhibited by high concentrations of retinol, as demonstrated by cell counting and [H]-thymidine incorporation. Moreover, the differentiation capacities of these cells were markedly and dose-dependently inhibited by retinol, as shown by the reduced expression of the lipogenic enzyme glycerol-3-phosphate dehydrogenase and by microscopic morphological analysis. These results strongly suggest that retinol, by inhibiting the ability of human preadipocytes to convert into mature adipocytes, could be of potential interest in the prevention of human adipose tissue development in general and of cellulitis in particular.

Bibliographic Details

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know