Periodically fluctuating protein kinases phosphorylate CLOCK, the putative target in the suprachiasmatic nucleus
Journal of Neurochemistry, ISSN: 0022-3042, Vol: 72, Issue: 5, Page: 2191-2197
1999
- 13Citations
- 16Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations13
- Citation Indexes13
- 13
- CrossRef10
- Captures16
- Readers16
- 16
Article Description
We studied nuclear protein phosphorylation in the rat suprachiasmatic nucleus (SCN) and found that a nuclear fraction of the SCN contained histone H1 kinase activity that periodically fluctuated with a diurnal rhythm, reaching a maximum at the midpoint of the light phase and a minimum at the midpoint of the dark phase. A p13(suc1)-bound fraction from the SCN nuclear fraction also exhibited diurnally fluctuating histone H1 kinase activity. Using in situ kinase assay, three histone H1 kinases, p45(PFK), p100(PFK), and p200(PFK) (termed periodically fluctuating protein kinases, or PFKs) were found in the p13(suc1)-bound fractions. p45(PFK) exhibited the highest level of light/dark cycle phosphorylation activity fluctuation. p45(PFK) highly phosphorylated the Ser-Pro-rich region of CLOCK, the putative physiological target. These results suggest that PFKs, especially p45(PFK) are involved in circadian clock-related signal transduction and gene expression, through the phosphorylation of target proteins such as CLOCK.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033011174&origin=inward; http://dx.doi.org/10.1046/j.1471-4159.1999.0722191.x; http://www.ncbi.nlm.nih.gov/pubmed/10217302; https://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.1999.0722191.x; https://dx.doi.org/10.1046/j.1471-4159.1999.0722191.x; https://onlinelibrary.wiley.com/doi/full/10.1046/j.1471-4159.1999.0722191.x
Wiley
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