Hyaluronan Exists in the Normal Stratum Corneum
Journal of Investigative Dermatology, ISSN: 0022-202X, Vol: 114, Issue: 6, Page: 1184-1187
2000
- 103Citations
- 62Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations103
- Citation Indexes103
- 103
- CrossRef87
- Captures62
- Readers62
- 62
Article Description
Hyaluronan is well known to exist as a water-sorbed macromolecule in the extracellular matrix. We here examined whether hyaluronan exists in the normal stratum corneum. High performance liquid chromatography was used to quantify hyaluronan content in the stratum corneum, epidermis (including stratum corneum), and dermis of mice, with the resulting dry weights being 22.3 ± 2.9, 15.1 ± 1.5, and 738.6 ± 31.6 μg per g, respectively. Normal mouse skin was then labeled with [ 3 H]-glucosamine in an organ culture, and accumulation of [ 3 H]-labeled hyaluronan and its molecular mass were determined separately for the stratum corneum, epidermis, and dermis. In the stratum corneum, [ 3 H]-labeled hyaluronan was accumulated linearly over the 3-d culture period. After the 3-d culture period, the epidermis synthesized twice the amount (expressed as dpm per mg dry weight) of [ 3 H]-labeled hyaluronan as the dermis, whereas the stratum corneum and dermis showed nearly the same content of [ 3 H]-labeled hyaluronan. The molecular mass of [ 3 H]-labeled hyaluronan was highest (>1.0 × 10 6 ) in the dermis and clearly lower (<6.0 × 10 4 ) in the stratum corneum. Based on these results, we here confirm that hyaluronan is supplied from keratinocytes beneath the stratum corneum layer, and is present in the normal stratum corneum. We speculate that hyaluronan may play a role in moisturizing the stratum corneum and/or regulating its mechanical properties.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0022202X15409017; http://dx.doi.org/10.1046/j.1523-1747.2000.00992.x; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0034130553&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/10844564; https://linkinghub.elsevier.com/retrieve/pii/S0022202X15409017
Elsevier BV
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