Antisense oligodesoxynucleotide strategies in renal and cardiovascular disease
Kidney International, ISSN: 0085-2538, Vol: 53, Issue: 6, Page: 1550-1558
1998
- 23Citations
- 4Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations23
- Citation Indexes23
- 23
- CrossRef13
- Captures4
- Readers4
Article Description
Antisense oligodesoxynucleotide strategies in renal and cardiovascular disease. Antisense oligodesoxynucleoties (ODN) provide a novel strategy to inhibit RNA transcription and thereby the synthesis of the gene product. Because antisense ODN hybridize with the mRNA strand, they are highly specific. Their backbone structure has been modified to phosphorothioates or phosphoamidates so that they can better withstand degradation after delivery. We have shown that antisense ODN are a useful research tool to elucidate intracellular processes. The example we provide involves the inhibition of PKC signaling. Furthermore, we have shown the potential clinical utility of antisense treatment. We successfully inhibited the expression of the surface adhesion molecule ICAM-1 with antisense ODN in a model of reperfusion injury. This model is highly applicable to the problem of delayed graft function in humans. However, “getting there” is a major problem and clearly less than half the fun. Cationic substances such as lipofectin have worked sufficiently well in the experimental setting. Viral gene transfer offers a possibility; however, viruses produce an additional series of problems. Liposomes may not provide sufficient transfer efficiency. Coating liposomes with viral fusion proteins may offer an ideal way with which to deliver the goods into the cytoplasm of the target cell.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0085253815305743; http://dx.doi.org/10.1046/j.1523-1755.1998.00927.x; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0031782465&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/9607185; https://linkinghub.elsevier.com/retrieve/pii/S0085253815305743
Elsevier BV
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