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Regulation of mesangial cell proliferation

Kidney International, ISSN: 0085-2538, Vol: 56, Issue: 4, Page: 1199-1207
1999
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Metric Options:   Counts1 Year3 Year

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Article Description

Regulation of mesangial cell proliferation. Regardless of the source of injury, an imbalance in the control of mesangial cell proliferation appears to play a direct role in the degree of progressive renal injury and glomerulosclerosis. Some of the regulatory mechanisms include specific soluble or non-soluble extracellular factors and a complex array of receptor-mediated signals that control the progression of the cell cycle or cell death. Understanding these regulatory processes could lead to novel therapeutic strategies to alleviate or arrest proliferative glomerular disease.

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