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Advances in GLP-1 receptor agonists for the treatment of type 2 diabetes

BIO Web of Conferences, ISSN: 2117-4458, Vol: 61
2023
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  • Captures
    2
  • Mentions
    1
    • News Mentions
      1
      • 1

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Sichuan University Researcher Reports Recent Findings in Type 2 Diabetes (Advances in GLP-1 receptor agonists for the treatment of type 2 diabetes)

2023 AUG 04 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Diabetes Daily -- Investigators discuss new findings in type 2 diabetes. According

Conference Paper Description

Glucagon-like peptide-1 (GLP-1), an incretin secreted by intestinal L cells, has become a critical target for the treatment of type 2 diabetes because of its physiological effects of augmenting insulin secretion, suppressing glucagon secretion, and decelerating gastric emptying. Human endogenous GLP-1 is found to be proteolytically degraded and inactivated by DPP-4, which considerably limits the therapeutic effects of GLP-1. In contrast, GLP-1RAs undergo significant improvement in drug stability. In this context, several successful strategies for the development of GLP-1RAs and the corresponding problems are fully elaborated. The assay gives a brief overview of the pharmacological effects, advantages and common adverse effects of GLP-1RAs, shedding light on the latest research progress of GLP-1RAs, including new dosage forms, new drug targets and new clinical applications.

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