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Chronic hepatitis C with repeatedly normal serum transaminases

Medecine/Sciences, ISSN: 0767-0974, Vol: 18, Issue: 3, Page: 357-361
2002
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Article Description

An estimated 25% of patients with chronic hepatitis C virus (HCV) infection have persistently normal serum alanine aminotransferose (ALAT). These patients have only mild hepatitis and they may either not progress to cirrhosis at all or progress at a much slower rate than persons with elevated serum ALT levels. Given the limited response to IFN and IFN-ribavirin combination therapy, it was recommended that these patients should not be usually treated. Because of the great improved response rate observed with pegIFN plus ribavirine, these recommendations will probably be discussed again in patients with a high probability of sustained response.

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