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I lead, follow me! How cells coordinate during collective migrations

Medecine/Sciences, ISSN: 1958-5381, Vol: 39, Issue: 8-9, Page: 619-624
2023
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Article Description

During development and wound healing, cells frequently move in a so-called collective cell migration' process. The same type of migration is used by some cancer cells during metastasis formation. A powerful model to study collective cell migration is the border cell cluster in Drosophila as it allows the observation and manipulation of a collective cell migration in its normal environment. This review describes the molecular machinery used by the border cells to migrate directionally, focusing on the mechanisms used to detect and reacts to chemoattractants, and to organise the group in leader and follower cells.

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