Progress in Platelet Medicine: Focus on Stent Thrombosis and Drug Resistance
Journal of Cardiothoracic and Vascular Anesthesia, ISSN: 1053-0770, Vol: 24, Issue: 4, Page: 722-727
2010
- 13Citations
- 43Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations13
- Citation Indexes13
- 13
- CrossRef10
- Captures43
- Readers43
- 43
Review Description
The outcome importance of coronary stent thrombosis has mandated the careful management of these devices and their associated platelet blockade during the perioperative period. Recent trials have highlighted the catastrophic outcomes after stent thrombosis. The maintenance of clinically effective platelet blockade not only is essential to prevent stent thrombosis but also to optimize outcome in the integrated management of acute coronary syndromes. Dual antiplatelet blockade with aspirin and clopidogrel must balance the risks of ischemia and bleeding in patients with acute coronary syndromes, especially in the subset who require urgent surgical coronary revascularization. Platelet resistance to thienopyridines such as clopidogrel and prasugrel may be a significant risk factor for adverse cardiovascular outcomes. This phenomenon is detectable by point-of-care assays although standardized definitions and standardized testing batteries have yet to be formulated. The determinants of platelet resistance to thienopyridine therapy include genetic polymorphisms (especially related to hepatic drug metabolism) and drug interactions (especially the proton pump inhibitors). Novel platelet blockers are currently in late clinical development and will likely induce more consistent platelet blockade because of pharmacokinetic advantages including the lack of hepatic metabolism for activation. These agents will likely supersede clopidogrel and prasugrel if randomized trials show superior efficacy and clinical safety.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1053077010001692; http://dx.doi.org/10.1053/j.jvca.2010.04.017; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77955710828&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/20561798; https://linkinghub.elsevier.com/retrieve/pii/S1053077010001692; https://dx.doi.org/10.1053/j.jvca.2010.04.017
Elsevier BV
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