In-vitro anti-proliferative effects of some anti-tumour drugs on feline mammary tumour cell lines
Research in Veterinary Science, ISSN: 0034-5288, Vol: 66, Issue: 3, Page: 169-174
1999
- 12Citations
- 8Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations12
- Citation Indexes12
- CrossRef12
- 12
- Captures8
- Readers8
Article Description
Six anti-tumour drugs namely; doxorubicin, mitoxantrone, vincristine, cisplatin, recombinant human tumour necrosis factor alpha (rh-TNFα) and recombinant feline interferon gamma (rf-IFNγ) were singly evaluated for their anti-proliferative effects on two feline cell lines (FRM and NAC) derived from mammary adenocarcinoma and grown as monolayers. We obtained concentration response curves that enabled the determination of the concentration inhibiting growth by 50 per cent (IC 50 ) for the chemotherapeutic agents with VCR exhibiting exponential-plateau curves. Differences in anti-proliferative effects of drugs to a given cell line and between the cell lines were also observed. NAC cells were relatively more resistant compared with FRM cells. The relative resistances for NAC cells were 4·19, 12·96, 0·05 and 2·10-fold to doxorubicin, mitoxantrone, vincristine and cisplatin, respectively. FRM cells were more resistant to VCR at lower concentrations compared with NAC cells. The cells appeared, at least in vitro, least sensitive to rh-TNFα and rf-IFNγ. rh-TNFα and rf-IFNγ were 23 and 29 per cent inhibitory to FRM cells and only 13 and 15 per cent inhibitory to NAC cells, respectively.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0034528898902181; http://dx.doi.org/10.1053/rvsc.1998.0218; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033053891&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/10333454; https://linkinghub.elsevier.com/retrieve/pii/S0034528898902181; https://dx.doi.org/10.1053/rvsc.1998.0218
Elsevier BV
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