PlumX Metrics
Embed PlumX Metrics

Age and Sex Influence Thyroid Hormone Effects in Target Tissues with Organ-Specific Responses

Experimental and Clinical Endocrinology and Diabetes, ISSN: 1439-3646, Vol: 128, Issue: 6-7, Page: 469-472
2020
  • 8
    Citations
  • 0
    Usage
  • 5
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Review Description

Age and sex impact prevalence and clinical features of thyroid disease. Thyroid dysfunction occurs with a higher frequency in elderly patients and females. Moreover, age alters clinical presentation of hyper- and hypothyroidism and onset of thyroid hormone (TH) related co-morbidities leading to increased risk for underdiagnosis and maltreatment in the elderly. Rodent models allow further insights into mechanisms of age- and sex-dependent TH action in target tissues. In this review, we summarize findings from mouse studies showing distinct effects of age and sex on systemic versus organ-specific TH action and discuss their wider implication for clinical care.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know