A novel self-assembling peptide for hemostasis during endoscopic submucosal dissection: A randomized controlled trial
Endoscopy, ISSN: 1438-8812, Vol: 53, Issue: 1, Page: 27-35
2021
- 72Citations
- 55Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations72
- Citation Indexes70
- 70
- Policy Citations2
- Policy Citation2
- Captures55
- Readers55
- 55
- Mentions1
- News Mentions1
- News1
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Article Description
Background Endoscopic submucosal dissection (ESD) is associated with a risk of bleeding. Bleeding is usually treated with diathermy, although this does carry a risk of mucosal thermal injury. Purastat is a topical hemostat that may be effective in controlling bleeding during ESD, thereby reducing the use of heat therapy. The aim of this study was to assess the reduction in heat therapy used in the interventional group (Purastat) compared with the control group. The secondary aims were to compare the procedure length, time for hemostasis, delayed bleeding rate, adverse events, and wound healing between the groups. Methods This was a single-center randomized controlled trial of 101 patients undergoing ESD. Participants were randomized to a control group where diathermy was used to control bleeding or an interventional group where Purastat could be used. Follow-up endoscopy was performed at 4 weeks to assess wound healing. Results There was a significant reduction in the use of heat therapy for intraprocedural hemostasis in the interventional group compared with controls (49.3 % vs. 99.6 %, P < 0.001). There were no significant differences in the procedure length, time for hemostasis, and delayed bleeding rate between the groups. Complete wound healing at 4 weeks was noted in 48.8 % of patients in the interventional group compared with 25.0 % of controls (P = 0.02). Conclusions This study has demonstrated that Purastat is an effective hemostat that can reduce the need for heat therapy for bleeding during ESD. It may also have a role in improving post-resection wound healing.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85094572643&origin=inward; http://dx.doi.org/10.1055/a-1198-0558; https://clinicaltrials.gov/ct2/show/NCT03567863; http://www.ncbi.nlm.nih.gov/pubmed/32679602; http://www.thieme-connect.de/DOI/DOI?10.1055/a-1198-0558; https://dx.doi.org/10.1055/a-1198-0558; https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1198-0558
Georg Thieme Verlag KG
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