Synthesis and antibacterial studies of phenethylamine alkaloid natural products along with their analogues: Discolin A, B, e and bacillimidazole B
Synlett, ISSN: 1437-2096, Vol: 35, Issue: 16, Page: 1872-1876
2024
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Article Description
The first total synthesis of phenethylamine alkaloid-based natural products discolin A, B, E and bacillimidazole B is reported, which were isolated from marine sea bacteria Tenacibaculum discolor sv11 and marine sponge. Total syntheses of discolin A, B, E and bacillimidazole B are achieved in two linear steps including condensation reaction and N-Alkylation reaction with an overall yield of 68%, 35%, 65%, and 32% respectively. A total of twenty-four analogues are prepared with moderate to excellent yield. All the natural products and their anlogues were screened for antibacterial activity. 8f shows lowest IC50 of 122.1 nM against P aeruginosa.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85184481466&origin=inward; http://dx.doi.org/10.1055/a-2256-5509; http://www.thieme-connect.de/DOI/DOI?10.1055/a-2256-5509; https://dx.doi.org/10.1055/a-2256-5509; https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2256-5509
Georg Thieme Verlag KG
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