PlumX Metrics
Embed PlumX Metrics

Synthesis and antibacterial studies of phenethylamine alkaloid natural products along with their analogues: Discolin A, B, e and bacillimidazole B

Synlett, ISSN: 1437-2096, Vol: 35, Issue: 16, Page: 1872-1876
2024
  • 0
    Citations
  • 0
    Usage
  • 2
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

The first total synthesis of phenethylamine alkaloid-based natural products discolin A, B, E and bacillimidazole B is reported, which were isolated from marine sea bacteria Tenacibaculum discolor sv11 and marine sponge. Total syntheses of discolin A, B, E and bacillimidazole B are achieved in two linear steps including condensation reaction and N-Alkylation reaction with an overall yield of 68%, 35%, 65%, and 32% respectively. A total of twenty-four analogues are prepared with moderate to excellent yield. All the natural products and their anlogues were screened for antibacterial activity. 8f shows lowest IC50 of 122.1 nM against P aeruginosa.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know