Biocatalytic One-Carbon Transfer - A Review

This review provides an overview of different Cbuilding blocks as substrates of enzymes, or part of their cofactors, and the resulting functionalized products. There is an emphasis on the broad range of possibilities of biocatalytic one-carbon extensions with Csources of different oxidation states. The identification of uncommon biosynthetic strategies, many of which might serve as templates for synthetic or biotechnological applications, towards one-carbon extensions is supported by recent genomic and metabolomic progress and hence we refer principally to literature spanning from 2014 to 2020. 1 Introduction 2 Methane, Methanol, and Methylamine 3 Glycine 4 Nitromethane 5 SAM and SAM Ylide 6 Other CBuilding Blocks 7 Formaldehyde and Glyoxylate as Formaldehyde Equivalents 8 Cyanide 9 Formic Acid 10 Formyl-CoA and Oxalyl-CoA 11 Carbon Monoxide 12 Carbon Dioxide 13 Conclusions.