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On the influence of the water electrostatic field on the amide group vibrational frequencies

Journal of Chemical Physics, ISSN: 0021-9606, Vol: 121, Issue: 16, Page: 7545-7548
2004
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Article Description

The spectra of clusters of N-methylacetamide (NMA) with water molecules was analyzed for testing the performance of fixed-charged approximation. At constant electrostatic potential, dispersion of vibrational frequencies was compared to distribution caused by geometry fluctuations. The point-charge electrostatic field was found to reproduce the solvent frequency shifts for NMA-water clusters of variable sizes and shapes, which was confirmed by extended tests. A set of electrostatic potentials on NMA atoms coming from water partial charges was obtained as average over the 11 configurations. The results show that for the NMA/HO systems, the point charge approximation reproduces the influence of the solvent on the solute.

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