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Biofunctionalized magnetic nanoparticles for high-sensitivity immunomagnetic detection of human C-reactive protein

Applied Physics Letters, ISSN: 0003-6951, Vol: 88, Issue: 25
2006
  • 55
    Citations
  • 0
    Usage
  • 22
    Captures
  • 0
    Mentions
  • 0
    Social Media
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Metrics Details

  • Citations
    55
    • Citation Indexes
      55
      • CrossRef
        42
      • Academic Citation Index (ACI) - airiti
        1
  • Captures
    22

Article Description

In this work, we developed immunomagnetic detection techniques for detecting human C-reactive protein (CRP). To enhance the technique's sensitivity to human CRP, biofunctionalized magnetic nanoparticles were used as markers, and a superconductive quantum interference device gradiometer system was adapted to measure the saturated magnetization of magnetically labeled CRP-anti-CRP immune complexes. Sensitivity for human CRP was found to be as high as 1 ng in 0.1 ml, i.e., 10 ng/ml in concentration. This sensitivity is much higher than that of conventional enzyme linked immunosorbent assay by one order of magnitude. © 2006 American Institute of Physics.

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