PlumX Metrics
Embed PlumX Metrics

Induced fit for mRNA/TIS11d complex

Journal of Chemical Physics, ISSN: 0021-9606, Vol: 131, Issue: 11, Page: 115103
2009
  • 33
    Citations
  • 0
    Usage
  • 12
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

TIS11d tandem zinc finger (TZF) domain can bind the class II AU-rich element of target mRNA and regulate mRNA turnover by promoting or inhibiting degradation. NMR spectra show that TIS11d undergoes a transition from disordered to well folded upon binding to Zn and mRNA. To gain an insight into the mechanism, we have performed explicit-solvent molecular dynamics simulations (MD) for both bound and apo-TIS11d to study the interdependence of binding and folding in the mRNA-TIS11d complex. These results are in qualitative agreement with NMR experiment. Furthermore, this method could be used to other study about protein folding upon ligand binding. © 2009 American Institute of Physics.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know