Migraine generator network and spreading depression dynamics as neuromodulation targets in episodic migraine
Chaos, ISSN: 1054-1500, Vol: 23, Issue: 4, Page: 046101
2013
- 26Citations
- 51Captures
- 3Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations26
- Citation Indexes26
- CrossRef26
- 24
- Captures51
- Readers51
- 51
- Mentions3
- Blog Mentions3
- Blog3
Article Description
Migraine is a common disabling headache disorder characterized by recurrent episodes sometimes preceded or accompanied by focal neurological symptoms called aura. The relation between two subtypes, migraine without aura (MWoA) and migraine with aura (MWA), is explored with the aim to identify targets for neuromodulation techniques. To this end, a dynamically regulated control system is schematically reduced to a network of the trigeminal nerve, which innervates the cranial circulation, an associated descending modulatory network of brainstem nuclei, and parasympathetic vasomotor efferents. This extends the idea of a migraine generator region in the brainstem to a larger network and is still simple and explicit enough to open up possibilities for mathematical modeling in the future. In this study, it is suggested that the migraine generator network (MGN) is driven and may therefore respond differently to different spatio-temporal noxious input in the migraine subtypes MWA and MWoA. The noxious input is caused by a cortical perturbation of homeostasis, known as spreading depression (SD). The MGN might even trigger SD in the first place by a failure in vasomotor control. As a consequence, migraine is considered as an inherently dynamical disease to which a linear course from upstream to downstream events would not do justice. Minimally invasive and noninvasive neuromodulation techniques are briefly reviewed and their rational is discussed in the context of the proposed mechanism. © 2013 AIP Publishing LLC.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84891407737&origin=inward; http://dx.doi.org/10.1063/1.4813815; http://www.ncbi.nlm.nih.gov/pubmed/24387580; https://pubs.aip.org/cha/article/23/4/046101/136043/Migraine-generator-network-and-spreading; http://scitation.aip.org/content/aip/journal/chaos/23/4/10.1063/1.4813815
AIP Publishing
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