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Mg shallow doping effects on the ac magnetic self-heating characteristics of γ-FeO superparamagnetic nanoparticles for highly efficient hyperthermia

Applied Physics Letters, ISSN: 0003-6951, Vol: 111, Issue: 18
2017
  • 10
    Citations
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  • 8
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  • Citations
    10
    • Citation Indexes
      9
    • Patent Family Citations
      1
      • Patent Families
        1
  • Captures
    8

Article Description

The effects of Mg doping on the magnetic and AC self-heating temperature rising characteristics of γ-FeO superparamagnetic nanoparticles (SPNPs) were investigated for hyperthermia applications in biomedicine. The doping concentration of nonmagnetic Mg cation was systematically controlled from 0 to 0.15 at. % in Mg-γFeO SPNPs during chemically and thermally modified one-pot thermal decomposition synthesis under bubbling O/Ar gas mixture. It was empirically observed that the saturation magnetization (M) and the out-of-phase magnetic susceptibility (χm″) of Mg-γFeO SPNPs were increased by increasing the Mg cation doping concentration from 0.05 to 0.13 at. %. Correspondingly, the AC magnetically induced self-heating temperature (T) in solid state and the intrinsic loss power in water were increased up to 184 °C and 14.2 nH mkg (Mg-γFeO, x = 0.13), respectively, at the biologically and physiologically safe range of AC magnetic field (H × f = 1.2 × 10 A ms). All the chemically and physically analyzed results confirmed that the dramatically improved AC magnetic induction heating characteristics and the magnetic properties of Mg-γFeO SPNPs (x = 0.13) are primarily due to the significantly enhanced magnetic susceptibility (particularly, χm″) and the improved AC/DC magnetic softness (lower AC/DC magnetic anisotropy) resulting from the systematically controlled nonmagnetic Mg cation concentrations and distributions (occupation ratio) in the Fe vacancy sites of γ-FeO (approximately 12% vacancy), instead of typically well-known FeO (no vacancy) SPNPs. The cell viability and biocompatibility with U87 MG cell lines demonstrated that Mg-γFeO SPNPs (x = 0.13) has promising bio-feasibility for hyperthermia agent applications.

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