The environmental pollutant pyrene induces the production of IL-4
Journal of Allergy and Clinical Immunology, ISSN: 0091-6749, Vol: 105, Issue: 4, Page: 796-802
2000
- 81Citations
- 13Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations81
- Citation Indexes80
- 80
- CrossRef66
- Policy Citations1
- Policy Citation1
- Captures13
- Readers13
- 13
Article Description
Background: Epidemiologic studies and experiments with mouse models suggest that polyaromatic hydrocarbons contained in, among others, diesel exhaust particles can promote the development of allergy. Objective: Because IL-4 organizes allergic responses in vivo, we have investigated whether pyrene, a major compound of diesel exhaust particles, can affect the production of IL-4. Methods: IL-4 production by primary human T cells was assessed by ELISA and messenger RNA transcription was detected by Northern blotting. Activation of the IL-4 promoter was tested in reporter gene assays with transiently transfected cell lines. Results: Pyrene induced transcription of IL-4 messenger RNA and expression of IL-4 protein in primary human T cells. Pyrene, but not related polyaromatic hydrocarbons, enhanced basal transcription of the human and mouse IL-4 promoter. Conclusion: Our results suggest that pyrene may promote allergic diseases by inducing the production of IL-4. (J Allergy Clin Immunol 2000;105:796-802.)
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0091674900963012; http://dx.doi.org/10.1067/mai.2000.105124; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0034102303&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/10756232; https://linkinghub.elsevier.com/retrieve/pii/S0091674900963012; https://dx.doi.org/10.1067/mai.2000.105124
Elsevier BV
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