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Total synthesis of (±)-Vibsanin e

Australian Journal of Chemistry, ISSN: 0004-9425, Vol: 62, Issue: 9, Page: 980-982
2009
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Conference Paper Description

Vibsanin E (1), a structurally rare complex diterpene, consisting of a compact 3-oxatricyclo[6.3.2.0] tridecane core and an unprecedented 3,3-dimethylacroyl enol ester functional group, formulate a considerable synthetic challenge. Williams and Davies failed to independently synthesize this nemesis, however, a 'two heads are better than one' approach delivered the first total synthesis of the molecule, since its diamond aniversary isolation. © CSIRO 2009.

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