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CD26 up-regulates expression of CD86 on antigen-presenting cells by means of caveolin-1

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 0027-8424, Vol: 101, Issue: 39, Page: 14186-14191
2004
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Article Description

CD26 is a T cell costimulatory molecule with dipeptidyl peptidase IV activity in its extracellular region. We previously reported that recombinant soluble CD26 enhanced T cell proliferation induced by the recall antigen tetanus toxoid (TT). However, the mechanism involved in this enhancement is not yet elucidated. We now demonstrate that CD26 binds Caveolin-1 on antigen-presenting cells, and that residues 201-211 of CD26 along with the serine catalytic site at residue 630 contribute to binding to caveolin-1 scaffolding domain. In addition, after CD26-caveolin-1 interaction on TT-loaded monocytes, caveolin-1 is phosphorylated, which links to activate NF-κB, followed by up-regulation of CD86. Finally, reduced caveolin-1 expression on monocytes inhibits CD26-mediated CD86 up-regulation and abrogates CD26 effect on TT-induced T cell proliferation. Taken together, these results strongly suggest that CD26-caveolin-1 interaction plays a role in the up-regulation of CD86 on TT-loaded monocytes and subsequent engagement with CD28 on T cells, leading to antigen-specific T cell activation.

Bibliographic Details

Ohnuma, Kei; Yamochi, Tadanori; Uchiyama, Masahiko; Nishibashi, Kunika; Yoshikawa, Noritada; Shimizu, Noriaki; Iwata, Satoshi; Tanaka, Hirotoshi; Dang, Nam H; Morimoto, Chikao

Proceedings of the National Academy of Sciences

Multidisciplinary

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