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CoRa—A general approach for quantifying biological feedback control

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 1091-6490, Vol: 119, Issue: 36, Page: e2206825119
2022
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Findings in Science Reported from University of California San Francisco (UCSF) (Cora-a General Approach for Quantifying Biological Feedback Control)

2023 JAN 27 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Science Daily -- Investigators discuss new findings in Science. According to news

Article Description

Feedback control is a fundamental underpinning of life, underlying homeostasis of biological processes at every scale of organization, from cells to ecosystems. The ability to evaluate the contribution and limitations of feedback control mechanisms operating in cells is a critical step for understanding and ultimately designing feedback control systems with biological molecules. Here, we introduce CoRa—or Control Ratio—a general framework that quantifies the contribution of a biological feedback control mechanism to adaptation using a mathematically controlled comparison to an identical system that does not contain the feedback. CoRa provides a simple and intuitive metric with broad applicability to biological feedback systems.

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