Stat5 as a Target for Regulation by Extracellular Matrix (∗)
Journal of Biological Chemistry, ISSN: 0021-9258, Vol: 270, Issue: 37, Page: 21639-21644
1995
- 146Citations
- 33Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations146
- Citation Indexes146
- 146
- CrossRef105
- Captures33
- Readers33
- 33
Article Description
Transcription of tissue-specific genes in mammary gland requires signals from both prolactin and basement membrane. Here we address the mechanism by which this specialized extracellular matrix regulates transcription. Using mammary cell cultures derived from transgenic mice harboring the ovine β-lactoglobulin gene, we show that either a basement membrane extract, or purified laminin-1, induced high levels of β-lactoglobulin synthesis. It is known that prolactin signals through Stat5 (signal transducer and activator of transcription). This transcription factor interacts with γ-interferon activation site-related motifs within the β-lactoglobulin promoter, which we show are required for matrix dependence of β-lactoglobulin expression. The DNA binding activity of Stat5 was present only in extracts of mammary cells cultured on basement membrane, indicating that the activation state of Stat5 is regulated by the type of substratum the cell encounters. Thus, basement membrane controls transcription of milk protein genes through the Stat5-mediated prolactin signaling pathway, providing a molecular explanation for previous studies implicating extracellular matrix in the control of mammary differentiation.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S002192581890222X; http://dx.doi.org/10.1074/jbc.270.37.21639; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0029155960&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/7665578; https://linkinghub.elsevier.com/retrieve/pii/S002192581890222X; https://dx.doi.org/10.1074/jbc.270.37.21639
Elsevier BV
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