Characterization of a HeLa Cell Factor Which Negatively Regulates Transcriptional Activation in Vitro by Transcriptional Enhancer Factor-1 (TEF-1) (∗)
Journal of Biological Chemistry, ISSN: 0021-9258, Vol: 270, Issue: 8, Page: 3631-3637
1995
- 12Citations
- 7Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations12
- Citation Indexes12
- CrossRef12
- 11
- Captures7
- Readers7
Article Description
A novel negatively acting factor has been identified and partially purified from HeLa and BJA-B cell extracts by chromatographic fractionation. Addition of this factor to HeLa cell extracts or to a reconstituted HeLa cell transcription system repressed transcriptional activation by a chimeric activator, GAL-TEF-1, containing the activation function of transcriptional enhancer factor-1 (TEF-1). In contrast, this factor did not repress transactivation by the chimeric GAL-VP16 activator. Repression of transactivation by GAL-TEF-1 could be alleviated by the addition of immunopurified HeLa cell TFIID, but not by increased quantities of GAL-TEF-1. These observations suggest that this negatively acting factor represses transactivation by interfering with the function of, or competing for, the TATA-binding protein-associated coactivators which mediate the activity TEF-1.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0021925818948386; http://dx.doi.org/10.1074/jbc.270.8.3631; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0028967314&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/7876100; https://linkinghub.elsevier.com/retrieve/pii/S0021925818948386; https://dx.doi.org/10.1074/jbc.270.8.3631
Elsevier BV
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