Chimeric Granulocyte/Macrophage Colony-stimulating Factor/Transforming Growth Factor-β (TGF-β) Receptors Define a Model System for Investigating the Role of Homomeric and Heteromeric Receptors in TGF-β Signaling *
Journal of Biological Chemistry, ISSN: 0021-9258, Vol: 271, Issue: 36, Page: 21758-21766
1996
- 44Citations
- 26Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations44
- Citation Indexes43
- 43
- CrossRef41
- Patent Family Citations1
- 1
- Captures26
- Readers26
- 26
Article Description
Transforming growth factor-β (TGF-β) belongs to a family of ligands that regulate cell growth and differentiation. The most commonly observed receptors are referred to as the type I, type II, and type III (betaglycan) TGF-β receptors. Two receptor models have been presented to account for the various cellular responses to TGF-β. The first proposes that all TGF-β signaling results from the formation of a heteromeric type I/type II complex, while the second suggests that distinct type I or type II TGF-β receptor combinations mediate aspects of TGF-β signaling. We have addressed this general question relating to TGF-β signaling by constructing chimeric receptors consisting of the extracellular domain of the granulocyte/macrophage colony-stimulating factor (GM-CSF) α or β receptor fused to the transmembrane and cytoplasmic domain of the type I or type II TGF-β receptor. Since high affinity GM-CSF binding requires dimerization of the α and β ligand binding subunits, the response elicited by defined type I and/or type II TGF-β receptor cytoplasmic domain homomers or heteromers can be examined. We show in mesenchymal AKR-2B cells that while TGF-β-dependent transient luciferase activity, endogenous gene activity, and long-term biological responses are similarly induced by activating the chimeric heteromeric receptors with GM-CSF as the endogenous TGF-β receptor, chimeric homomeric type I/type I or type II/type II receptors are signaling-incompetent.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0021925819618569; http://dx.doi.org/10.1074/jbc.271.36.21758; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0029832696&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/8702972; https://linkinghub.elsevier.com/retrieve/pii/S0021925819618569; https://dx.doi.org/10.1074/jbc.271.36.21758
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know