Influenza A Virus Induces Interleukin-27 through Cyclooxygenase-2 and Protein Kinase A Signaling *
Journal of Biological Chemistry, ISSN: 0021-9258, Vol: 287, Issue: 15, Page: 11899-11910
2012
- 61Citations
- 44Captures
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Metrics Details
- Citations61
- Citation Indexes61
- 61
- CrossRef60
- Captures44
- Readers44
- 44
Article Description
We previously reported that IL-27, which belongs to the IL-12 family of cytokines, is elevated in the serum of patients infected with influenza A virus (IAV). Here, we show that the expression of IL-27 was significantly up-regulated in A549 human lung epithelial cells and human peripheral blood mononuclear cells infected with IAV. Additionally, IAV triggered IL-27 expression through protein kinase A and cAMP-response element-binding protein signaling, which was mediated by cyclooxygenase-2-derived prostaglandin E 2. IL-27 inhibited IAV replication by STAT1/2/3 phosphorylation and activated antiviral factor protein kinase R phosphorylation. Clinical analysis showed that IL-27 levels were significantly elevated in a cohort of patients infected with IAV compared with healthy individuals and that circulating IL-27 levels were tightly and positively correlated with prostaglandin E 2 levels. These results indicate that IL-27 expression is one host immune factor produced in response to IAV infection and that elevated IL-27 levels inhibit viral replication.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0021925820531165; http://dx.doi.org/10.1074/jbc.m111.308064; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84859485114&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/22343630; http://www.jbc.org/lookup/doi/10.1074/jbc.M111.308064; https://syndication.highwire.org/content/doi/10.1074/jbc.M111.308064; https://linkinghub.elsevier.com/retrieve/pii/S0021925820531165; https://dx.doi.org/10.1074/jbc.m111.308064; http://www.jbc.org/content/287/15/11899; http://www.jbc.org/article/S0021925820531165/abstract; http://www.jbc.org/article/S0021925820531165/fulltext; http://www.jbc.org/article/S0021925820531165/pdf; https://www.jbc.org/article/S0021-9258(20)53116-5/abstract; http://www.jbc.org/cgi/doi/10.1074/jbc.M111.308064; http://www.jbc.org/content/287/15/11899.abstract; http://www.jbc.org/content/287/15/11899.full; http://www.jbc.org/content/287/15/11899.full.pdf; https://www.jbc.org/content/287/15/11899
American Society for Biochemistry & Molecular Biology (ASBMB)
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