Epithelial Cell Adhesion Molecule Regulates Tumor Initiation and Tumorigenesis via Activating Reprogramming Factors and Epithelial-Mesenchymal Transition Gene Expression in Colon Cancer *
Journal of Biological Chemistry, ISSN: 0021-9258, Vol: 287, Issue: 47, Page: 39449-39459
2012
- 99Citations
- 76Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations99
- Citation Indexes99
- 99
- CrossRef73
- Captures76
- Readers76
- 76
Article Description
Epithelial cell adhesion molecule (EpCAM) is highly expressed in epithelial-transformed neoplasia and tumor-initiated cells (TICs), but the role that EpCAM plays in the stemness properties of TICs is still unclear. Here we show that EpCAM and reprogramming factors (c-Myc, Oct4, Nanog, and Sox2) were concomitantly elevated in TICs, which were shown to have superior self-renewal, invasiveness, and tumor-initiating abilities. Elevation of EpCAM enhanced tumorsphere formation and tumor initiation. Knockdown of EpCAM inhibited the expressions of reprogramming factors and epithelial-mesenchymal transition genes, thereby suppressing tumor initiation, self-renewal, and invasiveness. In addition, EpCAM, especially intracellular domain of EpCAM (EpICD), bound to and activated the promoter of reprogramming factors. Treatment with the inhibitor of γ-secretase (DAPT) led to the blockage of the expressions of reprogramming factors and epithelial-mesenchymal transition genes, which was accompanied by the reduction of tumor self-renewal and invasion. Furthermore, the increased release of EpEX enhanced production of EpICD and regulated the expression of reprogramming factors. Together, these findings suggest that EpCAM plays an important role in regulating cancer-initiating abilities in TICs of colon cancer. This discovery can be used in the development of new strategies for cancer therapy.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0021925820622438; http://dx.doi.org/10.1074/jbc.m112.386235; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84869225084&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/22989882; https://linkinghub.elsevier.com/retrieve/pii/S0021925820622438; http://www.jbc.org/lookup/doi/10.1074/jbc.M112.386235; https://syndication.highwire.org/content/doi/10.1074/jbc.M112.386235; https://dx.doi.org/10.1074/jbc.m112.386235
Elsevier BV
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