Sustained High Protein-tyrosine Phosphatase 1B Activity in the Sperm of Obese Males Impairs the Sperm Acrosome Reaction *
Journal of Biological Chemistry, ISSN: 0021-9258, Vol: 289, Issue: 12, Page: 8432-8441
2014
- 16Citations
- 35Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations16
- Citation Indexes16
- 16
- CrossRef13
- Captures35
- Readers35
- 35
Article Description
Evidence of a causal link between male obesity and subfertility or infertility has been demonstrated previously. However, the mechanism underlying this link is incompletely understood. Here, we report that sustained high protein-tyrosine phosphatase 1B (PTP1B) activity in sperm of obese donors plays an essential role in coupling male obesity and subfertility or infertility. First, PTP1B level and activity were significantly higher in sperm from ob/ob mice than in wild-type littermates. High PTP1B level and activity in sperm was also observed in obese patients compared with non-obese donors. The enhanced sperm PTP1B level and activity in ob / ob mice and obese patients correlated with a defect of the sperm acrosome reaction (AR). Second, treating sperm from male ob / ob mice or obese men with a specific PTP1B inhibitor largely restored the sperm AR. Finally, blockade of sperm AR by enhanced PTP1B activity in male ob / ob mice or obese men was due to prolonged dephosphorylation of N -ethylmaleimide-sensitive factor by PTP1B, leading to the inability to reassemble the trans -SNARE complexes, which is a critical step in sperm acrosomal exocytosis. In summary, our study demonstrates for the first time that a sustained high PTP1B level or activity in the sperm of obese donors causes a defect of sperm AR and that PTP1B is a novel potential therapeutic target for male infertility treatment.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0021925820523417; http://dx.doi.org/10.1074/jbc.m113.517466; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84896997832&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/24519936; http://www.jbc.org/lookup/doi/10.1074/jbc.M113.517466; https://syndication.highwire.org/content/doi/10.1074/jbc.M113.517466; https://linkinghub.elsevier.com/retrieve/pii/S0021925820523417; https://dx.doi.org/10.1074/jbc.m113.517466; http://www.jbc.org/content/289/12/8432; http://www.jbc.org/article/S0021925820523417/abstract; http://www.jbc.org/article/S0021925820523417/fulltext; http://www.jbc.org/article/S0021925820523417/pdf; https://www.jbc.org/article/S0021-9258(20)52341-7/abstract; http://www.jbc.org/content/289/12/8432.abstract; http://www.jbc.org/content/289/12/8432.full; http://www.jbc.org/content/289/12/8432.full.pdf; https://www.jbc.org/content/289/12/8432; http://www.jbc.org/cgi/doi/10.1074/jbc.M113.517466
American Society for Biochemistry & Molecular Biology (ASBMB)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know