A Role for G 1 /S Cyclin-dependent Protein Kinases in the Apoptotic Response to Ionizing Radiation *
Journal of Biological Chemistry, ISSN: 0021-9258, Vol: 277, Issue: 41, Page: 38476-38485
2002
- 28Citations
- 14Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations28
- Citation Indexes27
- 27
- CrossRef22
- Policy Citations1
- Policy Citation1
- Captures14
- Readers14
- 14
Article Description
In Xenopus development the mid-blastula transition (MBT) marks a dramatic change in response of the embryo to ionizing radiation. Whereas inhibition of cyclin D1-Cdk4 and cyclin A2-Cdk2 by p27 Xic1 has been linked to cell cycle arrest and prevention of apoptosis in embryos irradiated post-MBT, distinct roles for these complexes during apoptosis are evident in embryos irradiated pre-MBT. Cyclin A2 is cleaved by caspases to generate a truncated complex termed ΔN-cyclin A2-Cdk2, which is kinase active, not inhibited by p27 Xic1, and not sensitive to degradation by the ubiquitin-mediated proteasome pathway. Moreover, ΔN-cyclin A2-Cdk2 has an expanded substrate specificity and can phosphorylate histone H2B at Ser-32, which may facilitate DNA cleavage. Consistent with a role for cyclin A2 in apoptosis, the addition of ΔN-cyclin A2-Cdk2, but not full-length cyclin A2-Cdk2, to Xenopus egg extracts triggers apoptotic DNA fragmentation even when caspases are not activated. Similarly, cyclin D1 is targeted by caspases, and the generated product exhibits higher affinity for p27 Xic1, leading to reduced phosphorylation of the retinoblastoma protein (pRB) during apoptosis. These data suggest that caspase cleavage of both cyclin D1-Cdk4 and cyclin A2-Cdk2 promotes specific apoptotic events in embryos undergoing apoptosis in response to ionizing radiation.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0021925818363300; http://dx.doi.org/10.1074/jbc.m206184200; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037063622&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/12176996; https://linkinghub.elsevier.com/retrieve/pii/S0021925818363300; http://www.jbc.org/lookup/doi/10.1074/jbc.M206184200; https://syndication.highwire.org/content/doi/10.1074/jbc.M206184200; https://dx.doi.org/10.1074/jbc.m206184200
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know