Cross-talk and Co-trafficking between ρ1/GABA Receptors and ATP-gated Channels *
Journal of Biological Chemistry, ISSN: 0021-9258, Vol: 279, Issue: 8, Page: 6967-6975
2004
- 52Citations
- 29Captures
- 2Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations52
- Citation Indexes52
- 52
- CrossRef42
- Captures29
- Readers29
- 29
- Mentions2
- References2
- Wikipedia2
Article Description
γ-Aminobutyric-acid (GABA) and ATP ionotropic receptors represent two structurally and functionally different classes of neurotransmitter-gated channels involved in fast synaptic transmission. We demonstrate here that, when the inhibitory ρ1/GABA and the excitatory P2X 2 receptor channels are co-expressed in Xenopus oocytes, activation of one channel reduces the currents mediated by the other one. This reciprocal inhibitory cross-talk is a receptor-mediated phenomenon independent of agonist cross-modulation, membrane potential, direction of ionic flux, or channel densities. Functional interaction is disrupted when the cytoplasmic C-terminal domain of P2X 2 is deleted or in competition experiments with minigenes coding for the C-terminal domain of P2X 2 or the main intracellular loop of ρ1 subunits. We also show a physical interaction between P2X 2 and ρ1 receptors expressed in oocytes and the co-clustering of these receptors in transfected hippocampal neurons. Co-expression with P2X 2 induces retargeting and recruitment of mainly intracellular ρ1/GABA receptors to surface clusters. Therefore, molecular and functional cross-talk between inhibitory and excitatory ligand-gated channels may regulate synaptic strength both by activity-dependent current occlusion and synaptic receptors co-trafficking.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0021925818446571; http://dx.doi.org/10.1074/jbc.m307772200; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=1342346558&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/14660627; https://linkinghub.elsevier.com/retrieve/pii/S0021925818446571; http://www.jbc.org/lookup/doi/10.1074/jbc.M307772200; https://syndication.highwire.org/content/doi/10.1074/jbc.M307772200; https://dx.doi.org/10.1074/jbc.m307772200
Elsevier BV
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