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Androgen Receptor Activation by G s Signaling in Prostate Cancer Cells *

Journal of Biological Chemistry, ISSN: 0021-9258, Vol: 280, Issue: 12, Page: 11583-11589
2005
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Article Description

The androgen receptor (AR) is activated in prostate cancer patients undergoing androgen ablative therapy and mediates growth of androgen-insensitive prostate cancer cells, suggesting it is activated by nonandrogenic factors. We demonstrate that activated α subunit of heterotrimeric guanine nucleotide-binding G s protein activates the AR in prostate cancer cells and also synergizes with low concentration of androgen to more fully activate the AR. The Gα s activates protein kinase A, which is required for the nuclear partition and activation of AR. These data suggest a role for Gα s and PKA in the transactivation of AR in prostate cancer cells under the environment of reduced androgen levels.

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