Androgen Receptor Activation by G s Signaling in Prostate Cancer Cells *
Journal of Biological Chemistry, ISSN: 0021-9258, Vol: 280, Issue: 12, Page: 11583-11589
2005
- 70Citations
- 29Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations70
- Citation Indexes70
- 70
- CrossRef62
- Captures29
- Readers29
- 29
Article Description
The androgen receptor (AR) is activated in prostate cancer patients undergoing androgen ablative therapy and mediates growth of androgen-insensitive prostate cancer cells, suggesting it is activated by nonandrogenic factors. We demonstrate that activated α subunit of heterotrimeric guanine nucleotide-binding G s protein activates the AR in prostate cancer cells and also synergizes with low concentration of androgen to more fully activate the AR. The Gα s activates protein kinase A, which is required for the nuclear partition and activation of AR. These data suggest a role for Gα s and PKA in the transactivation of AR in prostate cancer cells under the environment of reduced androgen levels.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0021925820808643; http://dx.doi.org/10.1074/jbc.m414423200; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=15744379004&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/15653681; https://linkinghub.elsevier.com/retrieve/pii/S0021925820808643; http://www.jbc.org/cgi/doi/10.1074/jbc.M414423200; https://syndication.highwire.org/content/doi/10.1074/jbc.M414423200; https://dx.doi.org/10.1074/jbc.m414423200
Elsevier BV
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