Non-enzymatic molecular damage as a prototypic driver of aging
Journal of Biological Chemistry, ISSN: 0021-9258, Vol: 292, Issue: 15, Page: 6029-6038
2017
- 52Citations
- 77Captures
- 1Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations52
- Citation Indexes52
- 52
- CrossRef47
- Captures77
- Readers77
- 77
- Mentions1
- Blog Mentions1
- 1
Most Recent Blog
A Tour of Some of the Molecular Damage Involved in Aging
The intricate molecular machinery found in cells only functions correctly when it is undamaged, meaning formed of the right atoms and bonds, and that often sizable structure correctly arranged into a particular three-dimensional shape. A cell is essentially a liquid bag of molecules that are constantly coming into contact with one another, however. Large numbers of these molecules react in inappro
Review Description
The chemical potentialities of metabolites far exceed metabolic requirements. The required potentialities are realized mostly through enzymatic catalysis. The rest are realized spontaneously through organic reactions that (i) occur wherever appropriate reactants come together, (ii) are so typical that many have proper names ( e.g. Michael addition, Amadori rearrangement, and Pictet-Spengler reaction), and (iii) often have damaging consequences. There are many more causes of non-enzymatic damage to metabolites than reactive oxygen species and free radical processes (the “usual suspects”). Endogenous damage accumulation in non-renewable macromolecules and spontaneously polymerized material is sufficient to account for aging and differentiates aging from wear-and-tear of inanimate objects by deriving it from metabolism, the essential attribute of life.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0021925820449415; http://dx.doi.org/10.1074/jbc.r116.751164; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85017578132&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/28264930; http://www.jbc.org/lookup/doi/10.1074/jbc.R116.751164; https://syndication.highwire.org/content/doi/10.1074/jbc.R116.751164; https://linkinghub.elsevier.com/retrieve/pii/S0021925820449415; https://dx.doi.org/10.1074/jbc.r116.751164
American Society for Biochemistry & Molecular Biology (ASBMB)
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