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Intercapillary distance, oxygen tension and local recurrence in cervix cancer

Scandinavian Journal of Clinical and Laboratory Investigation, ISSN: 0036-5513, Vol: 21, Issue: S106, Page: 145-157
1968
  • 173
    Citations
  • 0
    Usage
  • 17
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    173
    • Citation Indexes
      173
  • Captures
    17

Article Description

The vascularization of cervix cancer was studied by colpophotography. Assessment of the oxygenation of the tumour surface, using the intercapillary distance as parameter, revealed a gradual decrease in the oxygenation with advancing stage of the disease. This observation was confirmed by direct measurements of the tissue oxygen tension with an open-ended polarographic microelectrode. In invasive carcinoma of the cervix, hypoxic and anoxic foci were frequently encountered. The critical intercapillary idstance seemed to be approximately 350 μ since in cases with greater intercapillary distance the incidence of superficial necrosis rose rapidly. In 51 cases with a largest measured intercapillary distance of more than 400 μ local recurrence was found in 51.0 per cent during 5 years of follow-up, as compared to 16.7 per cent in 54 cases with intercapillary distance below 400 μ Out of 10 cases with a lowest observed tumour PO from zero to 9 mm Hg, 6 had local recurrences in the course of 4 years, as compared to 4 recurrences among 21 cases with a lowest observed tumor PO above 10 mm Hg. © 1968 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

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