Sc(OTf) catalysed multicomponent synthesis of chromeno[2,3-d]pyrimidinetriones under solvent-free condition
Synthetic Communications, ISSN: 1532-2432, Vol: 49, Issue: 3, Page: 431-443
2019
- 19Citations
- 6Captures
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Article Description
An efficient, simple, and environmentally friendly synthesis of a series of chromeno[2,3-d]pyrimidine-trione derivatives has been accomplished via the three-component reaction of a barbituric acid, dimedone/cyclohexane-1,3-dione, and aromatic aldehydes using Sc(OTf) as a recyclable catalyst under solvent-free condition. This method exploits the use of Sc(OTf) as a Lewis acid catalyst in organic synthesis and offers many rewards such as excellent product yield and easy work-up procedure. Harmless reaction conditions, as well as the absence of side-products, are another green aspects of this protocol.
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