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Effect of Butylated Hydroxytoluene and Butylated Hydroxyanisole on the Mutagenicity of 3,2’ -Dimethyl-4-aminobiphenyl

Nutrition and Cancer, ISSN: 1532-7914, Vol: 5, Issue: 3-4, Page: 153-158
1983
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This study was undertaken to investigate the possible antimutagenic effects of butylated hydroxyanisok (BHA) and butylated hydroxytoluene (BHT) on 3,2’-dimethyl-4-aminobiphenyl (DMAB)-induced mutagenicity, using the Ames Salmonella /mammalian microsome system. The addition of 100-250μg of BHT or 25–500μg of BHA/plate was found to inhibit DMAB-induced mutagenicity in Salmonella strains TA 98 and TA 100. In TA 100, the mutagenicity was further inhibited with the addition of S9 prepared from the livers of rats fed a 0.6% BHT diet as compared to S9 from the animals fed a diet containing no BHT. © 1983, Taylor & Francis Group, LLC. All rights reserved.

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