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Colonic cell proliferation in normal mucosa of patients with colon cancer

Acta Oncologica, ISSN: 0284-186X, Vol: 37, Issue: 1, Page: 65-71
1998
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Article Description

Cell kinetics parameters have been analysed in colonic mucosa at different distances from a tumour in patients with colon carcinoma. Total cell number (TCN), H thymidine labelling index (TLI), mitotic index (MI), Goblet cell index (GCI) and the distribution of labelled cells along the crypt column (cell position frequency plot) were determined in well-aligned crypts. Total cell number, GCI and the labelled cell position frequency plots were similar in different samples from the same individual. A negative linear correlation between TCN and TLI was observed. The analysis of the cell position plots showed two patterns 1) with a high concentration in the bottom fifth of the crypt and 2) with frequent labelled cells at high positions. Whereas a negative correlation between overall TLI and the percent contribution to the TLI of the lowermost fifth was seen, the correlation was positive for the next 3 fifths and labelling was absent in the last part of the crypt.

Bibliographic Details

Aldo Becciolini; Manuela Balzi; Paola Faraoni; Elena Tisti; Giorgia Zappoli Thyrion; Valentino Giachè; Luca Bandettini; Christopher S. Potten

MJS Publishing, Medical Journals Sweden AB

Medicine

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