Tenascin-C promotes migration of hepatic stellate cells and production of type I collagen
Bioscience, Biotechnology and Biochemistry, ISSN: 1347-6947, Vol: 80, Issue: 8, Page: 1470-1477
2016
- 8Citations
- 16Captures
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Metrics Details
- Citations8
- Citation Indexes8
- CrossRef8
- Captures16
- Readers16
- 16
Article Description
Tenascin-C (TN-C) is an extracellular matrix glycoprotein markedly upregulated during liver fibrosis. The study is performed to explore the role of TN-C during the growth and activation of hepatic stellate cells (HSCs). We found that TN-C was accumulated accompanying with the HSC activation. Our data on cell migration assay revealed that the rTN-C treatment enhanced HSC migration in a dose- and time-dependent manner, but did not influence their proliferation. HSCs transfected with pTARGET-TN-C overexpression vector displayed increased the type I collagen (Col I) production. TN-C overexpression enhanced the process of HSC activation through TGF-β1 signaling. Moreover, the anti-α9β1 integrin antibody treatment blocked the TN-C-driven Col I increase in rat HSCs. Collectively, TN-C had a positive role in activation of HSCs mediated by TGF-β1 and α9β1 integrin, manifesting elevation of Col I production and promotion of cell migration. Our results provide a potential insight for the therapy of hepatic fibrosis.
Bibliographic Details
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