PlumX Metrics
Embed PlumX Metrics

Interaction of phosolipid liposomes with a DNA model compound in irradiated systems

International Journal of Radiation Biology, ISSN: 0955-3002, Vol: 47, Issue: 5, Page: 497-508
1985
  • 3
    Citations
  • 0
    Usage
  • 2
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Phospholipid liposomes of different unsaturated fatty acid compositions were irradiated either in the presence of a double-stranded polynucleotide, or alone and then mixed with the polynucleotide. Changes in the structure of the polynucleotide were estimated by measuring its ability to form a fluorescent intercalation complex with ethidium bromide. The results imply that radiation-induced peroxidation of the polyunsaturated fatty acids of the phospholipid followed by transfer of damage to the polynucleotide was a very minor process in these systems. The results are discussed in terms of ·OH radical attack on the phospholipids at the polar head group or at saturated positions of the fatty acid chains near the water lipid interface. The intermediates produced by this process may then damage the polynucleotide. © 1985 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know