Chromosome aberrations induced in human lymphocytes by 16.5 mev protons
International Journal of Radiation Biology, ISSN: 0955-3002, Vol: 58, Issue: 6, Page: 999-1007
1990
- 23Citations
- 4Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations23
- Citation Indexes23
- 23
- CrossRef9
- Captures4
- Readers4
Article Description
In a track segment irradiation experiment with 16.5 MeV protons the induction of dicentrics was studied in human T-lymphocytes. The dose-response relationship was linear quadratic with estimated parameters α = (0.44 ± 0.07) × 10 Gy and β = (1.95 ± 0.30) × 10 Gy. With respect to X-rays a limiting RBE of 1.1-1.2 exists. The present findings are compared with data from other laboratories obtained with 4.9 and 8.7 MeV protons. It was found that the data do not fit theoretical predictions on a proportional relationship between α values and LET. Using the microdosimetric quantity y (25 nm), the dose average of the lineal energy, for characterization of these proton radiations, at a relevant site diameter of 25 nm the ratio of y = 1.15 is in accordance only with the observed α ratio of 1.0 ± 0.23 for 8.7 and 16.5 MeV protons. In contrast to the prediction of a constant β at low LET values, the quadratic coefficients increase with increasing LET between 3 and 8 keV/μm. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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