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Protein oligomerization in the bacterial outer membrane (Review)

Molecular Membrane Biology, ISSN: 0968-7688, Vol: 26, Issue: 3, Page: 136-145
2009
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Review Description

The formation of homo-oligomeric assemblies is a well-established characteristic of many soluble proteins and enzymes. Oligomerization has been shown to increase protein stability, allow allosteric cooperativity, shape reaction compartments and provide multivalent interaction sites in soluble proteins. In comparison, our understanding of the prevalence and reasons behind protein oligomerization in membrane proteins is relatively sparse. Recent progress in structural biology of bacterial outer membrane proteins has suggested that oligomerization may be as common and versatile as in soluble proteins. Here we review the current understanding of oligomerization in the bacterial outer membrane from a structural and functional point of view. © 2009 Informa UK Ltd.

Bibliographic Details

Meng, Guoyu; Fronzes, Rémi; Chandran, Vidya; Remaut, Han; Waksman, Gabriel

Informa UK Limited

Biochemistry, Genetics and Molecular Biology

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