PlumX Metrics
Embed PlumX Metrics

B-cell marker negative (CD7, CD19 ) Epstein-Barr virus-related pyothorax-associated lymphoma with rearrangement in the JH gene

Leukemia and Lymphoma, ISSN: 1042-8194, Vol: 44, Issue: 4, Page: 727-730
2003
  • 9
    Citations
  • 0
    Usage
  • 5
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Pyothorax-associated lymphoma (PAL) develops decades after receiving artificial pneumothorax for pulmonary tuberculosis. The lymphomas, develop in tissue affected by long-standing severe inflammatory process. Most cases demonstrate diffuse large B-cell lymphoma. We present a patient with T-cell phenotype-positive and B-cell phenotype-negative (CD7, CD43, CD19, and CD20) PAL. Southern blot hybridization using immunglobulin heavy chain J region (IgH) gene probe revealed a monoclonal rearrangement, and hybridization using T-cell receptor beta chain (TCR) gene probe revealed a germline configuration. This indicates that the tumor origin was of B-lymphocytes. Chromosomal abnormality of the lymphoma was complicated. It suggested that many transformations occurred. In the transformation process, probably B-cell antigens were lost, and T-cell antigens were aberrantly expressed.

Bibliographic Details

Tomita, Shigehisa; Mori, Kiyoshi L; Sakajiri, Sakura; Oshimi, Kazuo

Informa UK Limited

Medicine; Biochemistry, Genetics and Molecular Biology

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know