Study of ibuprofen glucopyranoside derivative synthesis by Candida antarctica lipase in organic solvent
Preparative Biochemistry and Biotechnology, ISSN: 1082-6068, Vol: 37, Issue: 1, Page: 27-38
2007
- 9Citations
- 4Captures
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Metrics Details
- Citations9
- Citation Indexes9
- CrossRef5
- Captures4
- Readers4
Article Description
The direct esterification of ibuprofen and methyl α-D-glucopyranoside in organic solvent by Novozym 435 was investigated in terms of the main variables controlling the process, including initial water activity (a , 0.05-0.75), incubation time, (0-168 h) and substrate concentration. The results showed that the lower initial a values resulted in higher enzymatic activity and bioconversion yield. The most appropriate initial a and incubation time were 0.06 and 144 h, respectively. The results also showed that the optimal ratio of ibuprofen to methyl α-D-glucopyranoside was 2.0. By optimizing these parameters, the yield increased about 50%. In addition, the product was confirmed to be methyl 6-O-(2′-(4′-isobutylphenyl) propionyl) D-α-glucopyranoside. Copyright © Taylor & Francis Group, LLC.
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