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Protective effect of polyphenol-rich extract on acute lung injury in influenza virus infected mice

Biotechnology and Biotechnological Equipment, ISSN: 1310-2818, Vol: 23, Issue: 3, Page: 1355-1359
2009
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Article Description

We have followed the anti-oxidant effects of a plant polyphenol-rich extract (PC) in the lungs of albino mice in the experimental influenza A/Aichi/2/68 (H3N2) (A/Aichi) virus infection. The effect of PC on the superoxide (O) and peroxide (HO) production from alveolar macrophages (aMØ) and on the lung antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) was studied. We also investigated the effect on the lipid peroxidation (LPO) and the total antioxidant activity (TAOA) in the lung tissue. All of the mentioned effects were studied in parallel with the protection on mortality rates and lung virological parameters on days 2, 6 and 9 after the viral challenge. It was shown that the extract significantly restored and stimulated the antioxidant activities in the lungs of influenza virus (IV)-infected mice. The protective effect of PC in the experimental influenza virus infection (EIVI) was related to both the specific antiviral effect of the extract and its antioxidant activity. © 2009 Taylor and Francis Group, LLC.

Bibliographic Details

J. Serkedjieva; T. Stefanova; E. Krumova; L. Tancheva

Informa UK Limited

Biochemistry, Genetics and Molecular Biology

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