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A new view of the spindle checkpoint

Journal of Cell Biology, ISSN: 0021-9525, Vol: 154, Issue: 5, Page: 909-911
2001
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Article Description

Previous studies of the spindle checkpoint suggested that its ability to prevent entry into anaphase was mediated by the inhibition of the anaphase-promoting complex (APC) ubiquitin ligase by Mad2. Two new studies challenge that view by demonstrating that another checkpoint protein, BubR1, is a far more potent inhibitor of APC function.

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