Synaptic activity prompts γ-secretase-mediated cleavage of EphA4 and dendritic spine formation
Journal of Cell Biology, ISSN: 0021-9525, Vol: 185, Issue: 3, Page: 551-564
2009
- 96Citations
- 133Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations96
- Citation Indexes96
- 96
- CrossRef87
- Captures133
- Readers133
- 133
Article Description
lzheimer's disease is an age-dependent neuro-degenerative disorder that is characterized by a pro-gressive decline in cognitive function. γ-secretase dysfunction is evident in many cases of early onset familial Alzheimer's disease. However, the mechanism by which γ-secretase dysfunction results in memory loss and neurodegeneration is not fully understood. Here, we demonstrate that γ-secretase is localized at synapses and regulates spine formation. We identify EphA4, one of the Ephrin receptor family members, as a substrate of γ-secretase, and fnd that EphA4 processing is enhanced by synaptic activity. Moreover, overexpression of EphA4 intracellular domain increases the number of dendritic spines by activating the Rac signaling pathway. These fndings reveal a function for EphA4-mediated intracellular signaling in the morphogenesis of dendritic spines and suggest that the processing of EphA4 by γ-secretase affects the pathogenesis of Alzheimer's disease. © 2009 Inoue et al.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=65649092174&origin=inward; http://dx.doi.org/10.1083/jcb.200809151; http://www.ncbi.nlm.nih.gov/pubmed/19414612; https://rupress.org/jcb/article/185/3/551/35541/Synaptic-activity-prompts-secretase-mediated; https://dx.doi.org/10.1083/jcb.200809151
Rockefeller University Press
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