GCC185 plays independent roles in Golgi structure maintenance and AP-1-mediated vesicle tethering
Journal of Cell Biology, ISSN: 0021-9525, Vol: 194, Issue: 5, Page: 779-787
2011
- 37Citations
- 40Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations37
- Citation Indexes37
- CrossRef37
- 34
- Captures40
- Readers40
- 40
Article Description
GCC185 is a long coiled-coil protein localized to the trans-Golgi network (TGN) that functions in maintaining Golgi structure and tethering mannose 6-phosphate receptor (MPR)-containing transport vesicles en route to the Golgi. We report the identification of two distinct domains of GCC185 needed either for Golgi structure maintenance or transport vesicle tethering, demonstrating the independence of these two functions. The domain needed for vesicle tethering binds to the clathrin adaptor AP-1, and cells depleted of GCC185 accumulate MPRs in transport vesicles that are AP-1 decorated. This study supports a previously proposed role of AP-1 in retrograde transport of MPRs from late endosomes to the Golgi and indicates that docking may involve the interaction of vesicle-associated AP-1 protein with the TGNassociated tethering protein GCC185. © 2011 Brown et al.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80052628194&origin=inward; http://dx.doi.org/10.1083/jcb.201104019; http://www.ncbi.nlm.nih.gov/pubmed/21875948; https://rupress.org/jcb/article/194/5/779/36465/GCC185-plays-independent-roles-in-Golgi-structure; https://dx.doi.org/10.1083/jcb.201104019; http://f1000.com/13244957#eval14598056; http://jcb.rupress.org/lookup/doi/10.1083/jcb.201104019; http://jcb.rupress.org/content/194/5/779; http://jcb.rupress.org/content/194/5/779.abstract; http://jcb.rupress.org/content/194/5/779.full.pdf; https://rupress.org/jcb/article-pdf/194/5/779/1353059/jcb_201104019.pdf; http://jcb.rupress.org/cgi/doi/10.1083/jcb.201104019; http://www.jcb.org/lookup/doi/10.1083/jcb.201104019; https://rupress.org/jcb/article-pdf/194/5/779/698085/jcb_201104019.pdf; http://www.jcb.org/cgi/doi/10.1083/jcb.201104019
Rockefeller University Press
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