Structure-function mapping of a heptameric module in the nuclear pore complex
Journal of Cell Biology, ISSN: 0021-9525, Vol: 196, Issue: 4, Page: 419-434
2012
- 103Citations
- 110Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations103
- Citation Indexes103
- CrossRef103
- 95
- Captures110
- Readers110
- 110
Article Description
The nuclear pore complex (NPC) is a multiprotein assembly that serves as the sole mediator of nucleocytoplasmic exchange in eukaryotic cells. In this paper, we use an integrative approach to determine the structure of an essential component of the yeast NPC, the ~600-kD heptameric Nup84 complex, to a precision of ~1.5 nm. The configuration of the subunit structures was determined by satisfaction of spatial restraints derived from a diverse set of negative-stain electron microscopy and protein domain-mapping data. Phenotypic data were mapped onto the complex, allowing us to identify regions that stabilize the NPC's interaction with the nuclear envelope membrane and connect the complex to the rest of the NPC. Our data allow us to suggest how the Nup84 complex is assembled into the NPC and propose a scenario for the evolution of the Nup84 complex through a series of gene duplication and loss events. This work demonstrates that integrative approaches based on low-resolution data of sufficient quality can generate functionally informative structures at intermediate resolution. © 2012 Fernandez-Martinez et al.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84859962733&origin=inward; http://dx.doi.org/10.1083/jcb.201109008; http://www.ncbi.nlm.nih.gov/pubmed/22331846; https://rupress.org/jcb/article/196/4/419/36788/Structure-function-mapping-of-a-heptameric-module; https://dx.doi.org/10.1083/jcb.201109008; http://jcb-dataviewer.rupress.org/jcb/doi/10.1083/jcb.201109008; http://jcb.rupress.org/cgi/doi/10.1083/jcb.201109008; http://jcb.rupress.org/content/196/4/419; http://jcb.rupress.org/content/196/4/419.abstract; http://jcb.rupress.org/content/196/4/419.full.pdf; http://www.jcb.org/cgi/doi/10.1083/jcb.201109008; https://rupress.org/jcb/article-pdf/196/4/419/702418/jcb_201109008.pdf; https://rupress.org/jcb/article-pdf/196/4/419/1355181/jcb_201109008.pdf; http://www.jcb.org/lookup/doi/10.1083/jcb.201109008; http://jcb.rupress.org/lookup/doi/10.1083/jcb.201109008
Rockefeller University Press
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