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A germinal center-independent pathway generates unswitched memory B cells early in the primary response

Journal of Experimental Medicine, ISSN: 0022-1007, Vol: 209, Issue: 3, Page: 597-606
2012
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Article Description

Memory B cells can be produced from the classical germinal center (GC) pathway or a less understood GC-independent route. We used antigen-based cell enrichment to assess the relative contributions of these pathways to the polyclonal memory B cell pool. We identified a CD38 GL7 B cell precursor population that differentiated directly into IgM or isotype-switched (sw) Ig memory B cells in a GC-independent fashion in response to strong CD40 stimulation. Alternatively, CD38 GL7 B cell precursors had the potential to become Bcl-6 GC cells that then generated primarily swIg memory B cells. These results demonstrate that early IgM and swIg memory B cells are products of a GC-independent pathway, whereas later switched Ig memory B cells are products of GC cells. © 2012 Taylor et al.

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