A germinal center-independent pathway generates unswitched memory B cells early in the primary response
Journal of Experimental Medicine, ISSN: 0022-1007, Vol: 209, Issue: 3, Page: 597-606
2012
- 290Citations
- 424Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations290
- Citation Indexes290
- 290
- CrossRef282
- Captures424
- Readers424
- 424
Article Description
Memory B cells can be produced from the classical germinal center (GC) pathway or a less understood GC-independent route. We used antigen-based cell enrichment to assess the relative contributions of these pathways to the polyclonal memory B cell pool. We identified a CD38 GL7 B cell precursor population that differentiated directly into IgM or isotype-switched (sw) Ig memory B cells in a GC-independent fashion in response to strong CD40 stimulation. Alternatively, CD38 GL7 B cell precursors had the potential to become Bcl-6 GC cells that then generated primarily swIg memory B cells. These results demonstrate that early IgM and swIg memory B cells are products of a GC-independent pathway, whereas later switched Ig memory B cells are products of GC cells. © 2012 Taylor et al.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84860363209&origin=inward; http://dx.doi.org/10.1084/jem.20111696; http://www.ncbi.nlm.nih.gov/pubmed/22370719; https://facultyopinions.com/prime/14187959#eval793458379; http://dx.doi.org/10.3410/f.14187959.793458379; https://facultyopinions.com/prime/14187959#eval15695059; http://dx.doi.org/10.3410/f.14187959.15695059; https://rupress.org/jem/article/209/3/597/41311/A-germinal-center-independent-pathway-generates; http://www.jem.org/lookup/doi/10.1084/jem.20111696; http://jem.rupress.org/content/209/3/597; http://f1000.com/14187959#eval15695059; http://www.jem.org/cgi/doi/10.1084/jem.20111696; https://rupress.org/jem/article-pdf/209/3/597/538648/jem_20111696.pdf; http://f1000.com/14187959#eval793458379; http://jem.rupress.org/content/209/3/597.abstract; http://jem.rupress.org/content/209/3/597.full.pdf; http://jem.rupress.org/lookup/doi/10.1084/jem.20111696; http://jem.rupress.org/cgi/doi/10.1084/jem.20111696
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